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Preparation of Pt-loaded SiNPs. (A) Synthetic scheme (B) TEM and high resolution TEM imaging of control SiNPs (i, iii) and Pt-loaded SiNPs (ii, iv), (Scale bar = 50 nm in (i, ii), and 10 nm in (iii. iv). (C) After 24 hrs preincubation in PBS, 48 % of the Pt remains stably bound in the SiNPs (pellet) (D) Pt released from the SiNPs after 24 hrs (supernatant in C) showed no toxicity on the NSCs up to 72 hrs after treatment.
