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. Author manuscript; available in PMC: 2017 Jul 18.
Published in final edited form as: Pain. 2009 Oct 22;147(1-3):277–286. doi: 10.1016/j.pain.2009.09.032

Figure 6. Skin IL-1 family cytokine levels after fracture.

Figure 6

IL-1β (A), IL-18 (B), IL-33 (C) and NGF (D) protein levels all increased in hindpaw skin at 4 weeks post-fracture but the increase in IL-33 did not reach significance. Systemic treatment with the SP NK1 receptor antagonist LY303870 for 8 days blocked the increased hindpaw skin expression of IL-1β, IL-18, and NGF after fracture. *p<0.05, **p<0.01 for fracture (n=8) vs control values (n=8). ###P<0.001, #p<0.05 for fracture (n=8) vs fracture+LY303870 (n=7).