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. 2016 Aug 24;2:16014. doi: 10.1038/npjbiofilms.2016.14

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Copyright © 2016 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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A high-fat diet reduces nutritional stress on AhR^−/− mice. Fasting glucose levels (a) and the oral glucose tolerance test (R36 AhR^+/+, n=5 and AhR^−/−, n=4; HFD AhR^+/+, n=6 and HFD AhR^−/−, n=4) (b), left panel: glucose changes over time; right panel: area under the curve (R36 AhR^+/+, n=5 and AhR^−/−, n=4; HFD AhR^+/+, n=6 and HFD AhR^−/−, n=4). (c) Quantitative RT-PCR results regarding the expression of Hmgcs2, PPARα, CD36, Cpt2, Acox, Cpt1a, and G6Pase in the livers of AhR^−/− and AhR^+/+ mice in response to high-fat diet (HFD) (R36 AhR^+/+, n=5 and AhR^−/−, n=4; HFD AhR^+/+, n=6 and HFD AhR^−/−, n=4). Gene expression was normalised to Hprt. *P<0.05, **P<0.01 against AhR^+/+ mice (Student’s t-test). (d) Effect of chow (R36) and HFD on plasma corticosterol levels in AhR^−/− and AhR^+/+ mice (R36 AhR^+/+, n=5 and AhR^−/−, n=4; HFD AhR^+/+, n=6 and HFD AhR^−/−, n=4). Corticosterol level was measured in plasma by ELISA. Bars and error bars depict the mean±s.e.m.