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. Author manuscript; available in PMC: 2018 Apr 15.
Published in final edited form as: Biochem Soc Trans. 2017 Apr 15;45(2):313–322. doi: 10.1042/BST20160145

Figure 3. CDK1 signaling is affected by elevations of O-GlcNAcylation.

Figure 3

Overexpression of OGT causes PLK1 expression to decrease. Reduced PLK1 leads to decreased MYT1 phosphorylation and increased protein expression. Subsequently, elevation of MYT1 expression increases CDK1 inhibitory phosphorylation. Furthermore, CDC25 (CDK1 phosphatase) that is activated by PLK1 has a lower mRNA level after OGT overexpression.