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. Author manuscript; available in PMC: 2018 Jun 15.
Published in final edited form as: Eur J Pharmacol. 2017 Mar 18;805:25–35. doi: 10.1016/j.ejphar.2017.03.034

Table 1.

Correlations of CM16 with protein synthesis inhibitors in the NCI 60-Cell-Line Screen using the COMPARE Algorithm.

Compound Correlation CM16 (NSC 779185) Information References
NSC 656902 0.744 Quassinoid tested by NCI among other quassionoids that were protein synthesis inhibitors Beutler et al. (2009)
PHYLLANTHOSIDE,S3′-DESACETYL – NSC 342443 0.723 Protein synthesis inhibitor (Phyllanthoside - NSC 328426) Chan et al. (2004); Garreau de Loubresse et al. (2014)
CHROMOMYCIN A3 – NSC 58514 0.722 1. Protein synthesis inhibitor
2. NF-kappaB inhibitor +effect on estrogen receptor
3. Effect on TRAIL and Wnt signaling pathways
1. Chan et al. (2004); Hsu et al. (2012); Mir and Dasgupta (2001)
2. Miller et al. (2010)
3. Toume et al. (2014)
MALFORMIN A – NSC 324646 0.713 1. Protein synthesis inhibitor (preventing IL-1 induced endothelial changes)
2. Effect on cell cycle
3. Fibrinolytic activity
4. Activity against cancerous cell lines
5. Cytotoxic effect on cancerous cell lines
6. Anti-Tobacco mosaic virus
1. Bannon et al. (1994)
2. Hagimori et al. (2007)
3. Koizumi et al. (2011)
4. Dobretsov et al. (2016); Li et al. (2013); Zhan et al. (2007)
5. Liu et al. (2015)
6. Tan et al. (2015)
5a – NSC 760180 0.713 Protein synthesis inhibitor Frédérick et al. (2012)
BOUVARDIN – NSC 259968 0.707 Protein synthesis inhibitor Chitnis et al. (1981); Gladstone et al. (2012); Stickel et al. (2015); Zalacaín et al. (1982)