Table 3:
GRADE Quality-of-Evidence Profile for the Primary Outcome of Stroke
| Comparison | Direct Evidence | Indirect Evidence | Network Meta-analysis | |||
|---|---|---|---|---|---|---|
| LAAC Device vs. NOACs | OR (95% Cr.I) | Quality of Evidence | OR (95% Cr.I) | Quality of Evidence | OR (95% Cr.I) | Quality of Evidence |
| All stroke | Not available | Not applicable | 0.85 (0.63–1.05) | ⊕⊕⊕O Moderatea | Same as indirect evidence | Same as indirect evidence |
| All-cause mortality | Not available | Not applicable | 0.71 (0.49–1.22) | ⊕⊕⊕O Moderate | Same as indirect evidence | Same as indirect evidence |
| Hemorrhagic stroke | Not available | Not applicable | 0.45 (0.29–0.79) | ⊕⊕⊕O Moderate | Same as indirect evidence | Same as indirect evidence |
| Ischemic stroke | Not available | Not applicable | 0.67 (0.24–1.64) | ⊕⊕⊕O Moderate | Same as indirect evidence | Same as indirect evidence |
Abbreviations: Cr.I, credible interval; LAAC device, left atrial appendage closure device with delivery system; NOAC, novel oral anticoagulant; OR, odds ratio.
a
Downgraded for indirectness.