Table 23:
# Studies (Design) | Risk of Bias | Inconsistency | Indirectness | Imprecision | Publication Bias | Upgrade Considerations | Quality |
---|---|---|---|---|---|---|---|
2 RCTs | No serious limitations | No serious limitations | No serious limitations | Serious limitations (−1)a | Undetected | None | ⊕⊕⊕ Moderate |
1 non-RCT | Serious limitations (−1)b | No serious limitations | Serious limitations (−1)c | Serious limitations (−1)a | Undetected | None | ⊕ Very low |
Abbreviations: GRADE, Grading of Recommendations Assessment, Development, and Evaluation; RCT, randomized controlled trial.
Not powered to detect differences.
GRADE starts at low for nonrandomized studies. Differences in baseline patient characteristics may affect duration.
Generalizability of results may be limited because of differences between health system contexts.