Figure 1.
High infiltration of CD68-positive cells is associated with tumor relapse but not with survival in triple-negative breast cancer. (a) Representative immunohistochemical staining of CD68 in tumor samples from TNBC patients with recurrence (left panel) and without recurrence (right panel). Scale bars represent 50 μm. (b) Kaplan–Meier analysis for relapse-free survival (left panel) and overall survival (right panel) according to the content of CD68-positive cells in tumor stroma. TNBC patients (N=203) were stratified by absent/moderate (0–2) or dense (3) macrophage infiltration. Curves were compared using log-rank test. P values and HR (95% CI in parentheses) are shown. CI, confidence interval; HR, hazard ratio; TNBC, triple-negative breast cancer.