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(a) Pie chart analysis of the coupling yields of ODN-1 with 543 carboxylic acids using DMT-MM and EDC/HOAt/DIPEA-mediated coupling, according to the conditions described in Figure 1, entries 1 and 8. (b) Histogram analysis of the coupling yields of structurally diverse carboxylic acids to ODN-1 with EDC/HOAt/DIPEA method. Benzoic (79 acids), primary (246 acids), secondary (47 acids), and tertiary carboxylic acids (17 acids), heterocyclic acids (154 acids).
