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. Author manuscript; available in PMC: 2018 Jun 13.
Published in final edited form as: Circulation. 2017 May 12;135(24):2373–2388. doi: 10.1161/CIRCULATIONAHA.116.026560

Figure 2c. Associations of adiposity with risk of T2D from observational and Mendelian randomization analyses.

Figure 2c

Association between T2D and adiposity (BMI and WHRadjBMI) comparing causal odds ratios (OR) per SD of adiposity trait derived from instrumental variable analysis and observational analysis from Vazquez et al., 20072. Causal estimates are derived from Mendelian randomization and include conventional (ratio) approach and weighted median (see Methods for further details). P(genetic pleiotropy) relates to the P-value derived from the intercept of MR-Egger; a small P-value denotes presence of directional pleiotropy.