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. Author manuscript; available in PMC: 2017 Jul 18.
Published in final edited form as: Nature. 2016 Sep 7;538(7625):344–349. doi: 10.1038/nature19804

Extended Data Figure 2. Resistance selection of BRD38427 and BRD1095.

Extended Data Figure 2

a, Over 3 months of intermittent and increasing resistance selection pressure of BRD73842 starting at 150 nM (EC99.9) or 0.5 µM (10× EC50) yielded two cultures showing a 13- to 16-fold EC50 shift. Two clonal lines from each culture were developed and subjected to whole-genome sequencing. b, Over 3 months of intermittent pressure of BRD1095 at 60 nM (EC99.9) or 150 nM (10 ×EC50) yielded three cultures showing a 3- to 67-fold EC50 shift. Two clonal lines from each culture were developed and subjected to whole-genome sequencing.