Table 2. Sensitivities, specificities, diagnostic accuracy, area under the curve, significance, and 95% confidence intervals for the assessment of each single parameter, and MP [11C]Acetate PET-MRI with one to five parameters.
| Sensitivity | Specificity | Accuracy | AUC6 | p7 | Asymptotic 95% Confidence Interval | ||
|---|---|---|---|---|---|---|---|
| Lower Bound | Upper Bound | ||||||
| Single parameter | |||||||
| T2w1 | .950 | .588 | .839 | .788 | .001 | .634 | .941 |
| DWI2 | .950 | .500 | .804 | .725 | .009 | .559 | .891 |
| 1H-MRSI3 | .650 | .625 | .625 | .638 | .110 | .475 | .800 |
| DCE4 | .775 | .563 | .714 | .669 | .050 | .504 | .833 |
| PET5 | .775 | .313 | .643 | .544 | .612 | .373 | .715 |
| Combination with two parameters | |||||||
| T2w and DWI | .950 | .688 | .875 | .819 | .000 | .674 | .963 |
| T2w and 1H-MRSI | .650 | .688 | .661 | .669 | .050 | .511 | .827 |
| T2w and DCE | .775 | .750 | .768 | .763 | .002 | .618 | .907 |
| T2w and PET | .750 | .688 | .714 | .719 | .011 | .565 | .873 |
| Combination with three parameters | |||||||
| T2w, DWI and 1H-MRSI | .950 | .625 | .857 | .788 | .001 | .634 | .941 |
| T2w, DWI and DCE | .950 | .563 | .839 | .756 | .003 | .596 | .917 |
| T2w, DWI and PET | .950 | .438 | .804 | .694 | .025 | .523 | .864 |
| Combination with four parameters | |||||||
| T2w, DWI, 1H-MRSIand DCE | .950 | .563 | .839 | .756 | .003 | .596 | .917 |
| T2w, DWI, 1H-MRSI and PET | .950 | .500 | .821 | .725 | .009 | .559 | .891 |
| T2w, DWI, DCE and PET | .950 | .563 | .839 | .756 | .003 | .596 | .917 |
| Combination with five parameters | |||||||
| T2, DWI, 1H-MRSI, DCEand PET | .900 | .563 | .804 | .731 | .007 | .570 | .893 |
1 T2-weighted MRI
2 diffusion-weighted imaging
3 three-dimensional proton MR spectroscopic imaging
4 dynamic contrast-enhanced MRI
5 positron emission tomography
6 area under the ROC curve
7 significance