Fig 7. Normalized Frequencies of E-boxes and of the NE motif AACGTT at MYC-occupied genomic loci in human P493-6 B-cells.

MYC-bound sequences were obtained from ChIP-seq data of P493-6 cells overexpressing MYC [22]. The frequencies of all ten possible E-boxes (CANNTG), the NE motif AACGTT, and two control (Ctrl) sequences under MYC ChIP-seq peaks (A) and summits (B) were normalized to the occurrence of each motif in the human genome. The summits are the ±100 bp region from the apex of ChIP-seq peaks. The normalized frequencies are shown for all MYC peaks/summits (left) and for the most significant MYC peaks/summits (top 33% based on p-value; right).