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. 2017 Jul 18;12(7):e0181015. doi: 10.1371/journal.pone.0181015

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© 2017 Leiss et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 1 — A, Anti-dsDNA IgG antibody levels were significantly lower in mir155-deficient PIL^-/- than in lupus wild type PIL^+/+. Both pristane-induced groups, PIL^+/+ and PIL^-/-, had significantly increased antibody levels compared to CO^+/+. B, C, In addition, PIL^-/- also had lower levels of anti-chromatin-antibodies and anti-histone-antibodies than PIL^+/+. Antibody levels in PIL^-/- were only slightly elevated compared to CO^+/+. Results are representative of 2 independent experiments. PIL were induced with pristane, CO with PBS; ^+/+ stands for wild type, ^-/- for miR155-deficient knockouts; bars show mean with SD. * = P < 0.05, by Mann-Whitney test.