Fig 3. Chemical stresses prolonged the decay rates of LINC00152 and MALAT1, but did not affect transcription rates.

The transcription rates of (A) LINC00152 and (B) MALAT1 were determined in control cells (black bar) and chemical-stressed cells (gray bar). Nascent LINC00152 and MALAT1 were transcribed with the incorporation of EU. Relative EU-RNA quantity indicated the total amount of EU-labeled RNA captured was divided by the input RNA amount, and indicated the transcription rate. The decay rates of (A) LINC00152 and (B) MALAT1 were determined in control cells (solid circle and black bar) and in chemical-stressed cells (open circle and gray bar). Values represent mean ± SD obtained from three independent experiments (*P < 0.05, Student’s t test).