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. Author manuscript; available in PMC: 2018 Jul 5.
Published in final edited form as: Neuroreport. 2017 Jul 5;28(10):618–624. doi: 10.1097/WNR.0000000000000811

Figure 3. Calcineurin inhibition by FK506 reverses spine loss in APOE4 targeted replacement mice.

Figure 3

A) Four day peripheral administration of 100 mg/kg FK506 results in a decreased calcineurin activity in both APOE3 and APOE4 mouse cortex. B) Spine density quantification of apical oblique dendrites. C) Spine head width of apical oblique dendritic spines. D) Representative images of the Golgi stained AO dendrites following vehicle or FK506 treatment. Two way ANOVA with Bonferroni multiple comparisons. * = P < 0.05 vs APOE3 vehicle; ** = P < 0.01 vs APOE3 vehicle; +++ = P < 0.001 vs APOE4 vehicle; ++++ = P < 0.0001 vs APOE4 vehicle.