Table 2. Genes involved in extracellular matrix homeostasis significantly modulated (fold change ⩾1.5, P⩽0.05) in space (S) versus ground (G) mice.

Gene symbol	Gene title	Fold change S/G	P-value a
Structural macromolecules and post-translational enzymes
Col1a1	Collagen, type I, alpha1	1.53	0.045
Emilin2	Elastin microfibril interfacer 2	−2.55	0.029
Pcolce2	Procollagen C-endopeptidase enhancer2	−1.72	0.034
P4ha1	Procollagen-proline 4-hydroxylase	−1.59	0.010
Matricellular proteins
Tnxb	Tenascin XB	−1.69	0.017
Cyr 61/CCN1	Cysteine rich protein 61	2.84	0.004
Ctgf/CCN2	Connective tissue growth factor	2.65	0.001
Hyaluronan synthesis
Has2	Hyaluronan synthase 2	−1.85	0.031
Dermo-epidermal junction
Col4a4	Collagen, type IV, alpha 4	−1.72	0.040
Col7a1	Collagen, type VII, alpha 1	1.73	0.010
Lama2	Laminin, alpha 2	−1.68	0.034
Matrix degradation
Adamts1	A disintegrin-like and metallopeptidase with thrombospondin type 1 motif, 1	1.57	0.002
Adamts9	A disintegrin-like and metallopeptidase with thrombospondin type 1 motif, 9	1.69	0.035
Plau	Plasminogen activator, urokinase	−2.19	0.002
Serpine 1 (PAI1)	Serine peptidase inhibitor, clade E, member 1	3.96	0.010
Cell–matrix interactions
Itga1	Integrin alpha 1	−2.08	0.024
Itgb1	Integrin beta 1	2.07	0.005
Itgb1bp2	Integrin beta 1 binding protein 2	2.57	0.000
Itgb2	Integrin beta 2	−2.03	0.047
Ddr2	Discoidin domain receptor, member 2	−1.50	0.026

^aStudent’s t-test.