Skip to main content
. 2016 Aug 17;7(17):3452–3457. doi: 10.1021/acs.jpclett.6b01525

Figure 1.

Figure 1

Putative binding sites (blue circles) identified on the MDM2 surface (white). (A) Benzene occupancy maps (black mesh) overlaid on the structure of MDM2 complexed with nutlin-2 (PDB code 1RV1), showing detection of the second nutlin interaction site. The neighboring protomer is represented as white cartoon. (B) Residues forming the second nutlin interaction site. (C) Benzene occupancy maps overlaid on the structure of MDM2 complexed with p53 peptide (PDB code 1YCR), showing detection of the proximal P27 binding site. (D) Residues forming the proximal P27 binding site.