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. 2016 Aug 17;7(17):3452–3457. doi: 10.1021/acs.jpclett.6b01525

Figure 2.

Figure 2

Design of extended stapled peptides. (A) A Phe residue (green) was appended to the C-terminus of the WT p53 peptide (PDB code 1YCR) such that it overlapped with the benzene molecule (orange) bound in the second nutlin interaction site. (B) Conformation of YS-1 after 50 ns of MD simulation.