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Crystal structures of MDM2 (green with translucent surface) bound to YS-1 and YS-2 (PDB codes 4UE1 and 4UD7, respectively). (A) MDM2 bound to YS-1 (yellow) with YS-2 (orange) superimposed. (B) Interactions of Tyr30 within the proximal P27 site, with hydrogen bonds represented as dashed lines.
