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. 2016 Jan 21;2:15022. doi: 10.1038/npjmgrav.2015.22

Table 4. Downregulated gene expression of the TCA cycle components.

Gene name Coding protein Expression change log2[μG/1 G] t-test P-value
pdha-1 Pyruvate dehydrogenase (Lipoamide) α1 −0.45 0.00
C04C3.3 Pyruvate dehydrogenase complex E1 β subunit −0.36 0.00
dld-1 Dihydrolipoamide dehydrogenase −0.54 0.00
cts-1 Citrate synthase −0.76 0.00
aco-1 Aconitase −0.32 0.00
aco-2 Aconitase −0.14 0.01
idha-1 NAD+-dependent mitochondrial isocitrate dehydrogenase α subunit −0.64 0.00
idhb-1 NAD+-dependent mitochondrial isocitrate dehydrogenase β subunit −0.38 0.00
idhg-1 NAD+-dependent mitochondrial isocitrate dehydrogenase γ subunit −0.30 0.00
idhg-2 NAD+-dependent mitochondrial isocitrate dehydrogenase γ subunit −0.56 0.00
idh-2 Mitochondrial isocitrate dehydrogenase −0.30 0.00
gei-7 Isocitrate lyase/malate synthase −1.09 0.00
dlst-1 Dihydrolipoamide S-succinyltransferase −0.43 0.01
dld-1 Dihydrolipoamide dehydrogenase −0.54 0.00
sdha-1 Succinate dehydrogenase complex, subunit A −0.67 0.01
sdhb-1 Succinate dehydrogenase complex, subunit B −0.56 0.00
mev-1 Succinate dehydrogenase complex, subunit C −0.76 0.00
sdhd-1 Succinate dehydrogenase complex, subunit D −0.60 0.00
fum-1 Fumarase −0.56 0.00
mdh-1 Malate dehydrogenase −0.38 0.00