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. Author manuscript; available in PMC: 2017 Jul 18.
Published in final edited form as: Autophagy. 2012 Jun 6;8(8):1271–1272. doi: 10.4161/auto.20872

Figure 1.

Figure 1

A model of the mechanism by which the Ypt1 GTPase module regulates PAS assembly during the selective Cvt pathway. In yeast, TRAPPIII, which contains the essential TRAPPI subunits, Bet3, Bet5, Trs23, Trs31 and Trs20, as well as the autophagy-specific subunit Trs85, acts as a GEF for Ypt1 during selective autophagy. Activated Ypt1 interacts with Atg11, an adaptor for Atg19, the Ape1 cargo receptor. This interaction is required for assembly of PAS components during the Cvt pathway, e.g., Atg11, Atg8 and Atg1. Human orthologs of the yeast machinery components are shown on the right.