The RBC storage lesion. The changes affect the RBC cytoplasm and more so the membrane, parts of which are shed into the supernatant as microvesicles.
RBC, red blood cell; 2,3-DPG, 2,3-diphosphoglycerate; ATP, adenosine triphosphate; ADP, adenosine diphosphate; AMP, adenosine monophosphate; IL, interleukin; TNF, tumour necrosis factor.