. Author manuscript; available in PMC: 2017 Jul 18.

Published in final edited form as: Br J Haematol. 2014 Jan 25;165(1):3–16. doi: 10.1111/bjh.12747

Table IV.

Assessment of the effects of RBC storage time on various physiological parameters in healthy volunteers

Reference	Autologous RBC in crossover design		RBC characteristics		Outcome parameters	Summary of results	Country	Trial registration
Reference	Volun-teers (n)	RBC (n)	RBC storage time	Leuco-reduction	Outcome parameters	Summary of results	Country	Trial registration
Weiskopf et al, (2006)	9	2	3.4 h versus 23 days (median)	No	Anaemia-induced cognitive dysfunction	No difference in reversal of dysfunction	USA
Hod et al, (2011)	14	2	3 to 7 days versus 40 to 42 days	Yes	Iron, extravascular haemolysis, metabolism parameters, inflammation, bacterial growth in vitro	Significant changes in iron and extravasular haemolysis parameters only	USA	NCT01319552
Berra et al, (2012)	9	1	3 days versus 40 days	Yes	Reactive hyperaemia index (reactive hyperperfusion)	No difference in hyperaemia index	USA
Weiskopf et al, (2012)	35	2	1.7 h versus 24.5 days	Yes	Pulmonary function (gas exchange variables)	Equivalent slight declines in variables	USA

RBC, red blood cell.