Figure 8. Limits on inferring the Laplace transform of simulated pairwise coalescence distributions.

Symbols and colors are as in the bottom left panel of Figure 6. Top: MAGIC can usually accurately infer the Laplace transform from ${10}^8$ sequenced bases (top row), but often fails when the data is limited to ${10}^7$ bases (bottom row, right two panels). Even under limited data, the inferences that it does manage to make remain accurate (bottom row, left panel). Other simulation parameters are as in the top row of Figure 2. Bottom: MAGIC can infer most of the Laplace transform when the crossover rate, $\rho$, is less than the mutation rate, $\mu$ (left two panels), but for ${\displaystyle \rho >\mu }$ (right panel), it becomes limited to large $z$. Simulation parameters are as in the top left panel of Figure 2, with $\rho$ increased.

DOI: http://dx.doi.org/10.7554/eLife.24836.009