Table 1.
Stricture formation after esophageal mucosal resection (EMR) in pigs: effect of use of stents covered with a biological extracellular matrix (ECM) mesh. Control animals after one week (week 1), and treatment groups after one week without stent (week 4). SIS, small intestine submucosa (Biodesign); ADM, acellular dermal matrix (Strattice); UBM, urinary bladder matrix (Matristem).
| Control (week 1) | Stent-only (week 4) | Stent with biological mesh (week 4) | |||
|---|---|---|---|---|---|
| +SIS | +ADM | +UBM | |||
| Number of animals, n | 5 | 5 | 5 | 4 | 5 |
| Esophageal diameter, % reduction, mean (SD) | 62.2 (12.9) | 82.0 (8.3)1 | 86.5 (7.5)1 | 94.4 (1.9)1,2 | 94.0 (6.9)1,2 |
| Lesion length, % of baseline length, mean (SD) | 77.6 (12.4) | 49.6 (11.7)1 | 43.0 (25.1) | 38.5 (8.8)1 | 32.0 (6.2)1,2 |
| Proximal dilation, percent, mean (SD) | 128.2 (6.2) | 203.5 (19.8)1 | 198.6 (24.6)1 | 203.7 (25.6)1 | 195.9 (30.4)1 |
1
P<0.05; at week 4 vs. Control at week 1
2
P<0.05; at week 4 vs. Stent-only at week 4.