Table 2.
Summary of toxin relationships with ancestral proteins
| Toxin type | Nearest ancestral protein match |
|---|---|
| 3FTx | Part of a polytomy that includes the nicotinic acetylcholine receptor binding LYNX (e.g., Q9BZG9 from Homo sapiens [Human]) and SLUR peptides (e.g., P55000 from Homo sapiens). |
| Acetylcholinesterase | Vertebrate acetylcholinesterase (e.g., P36196 from Gallus gallus). |
| ADAM | Sister group to the ADAM 7 and ADAM 28 clades. |
| BNP | Related to the variable BNP forms. |
| Cobra venom factor | Complement C3 sequence Q01833 from Naja naja (Spectacled cobra). |
| CNP-BPP | CNP-BPP Q9PW56 from Bothrops jararaca (Jararaca). |
| CRISP | CRISP protein subclade that includes Q91055 (helothermine) from Heloderma horridum (Beaded lizard). |
| Crotamine | Crotasin (Q6HAA2) from Crotalus durissus terrificus (Neotropical Rattlesnake). |
| Cystatin | Sister group to the E/M/N type cystatins. |
| Factor V | Factor V (Q804X4) from Gallus gallus (Chicken). |
| Factor X | Factor X (P25155) from Gallus gallus (Chicken). |
| Kallikrein | Nearest neighbor is P43685 (gilatoxin) from Heloderma horridum (Beaded lizard) and this clade is then sister group to the tissue (glandular) kallikrein clade. |
| Kunitz | Overall protein family a polytomy. |
| L-amino oxidase | Vertebrate L-amino oxidase. |
| Lectin | Unresolved but within main lectin clade. |
| Mamba intestinal toxin | Sister group to the prokineticin 2 clade. |
| Nerve growth factor | β NGF. |
| PLA2 (type IB) | Endogenous type IB PLA2 (e.g., Q8JFG2 from Laticauda semifasciata). |
| PLA2 (type IIA) | Endogenous type IIA PLA2. |
| Sarafotoxin | Sister group to endothelin-3. |
| SPRY | Weakly related to proteins of hemopoietic origin. |
| VEGF | Relationships unresolved. |
| Wagerlin | No endogenous protein match currently known. |
| Waprin | Relationships unresolved. |