Table 3.

Tissue specificities of the ancestral body proteins

Ancestral protein	Tissue location
Acetylcholinesterase	Muscle
ADAM 7 and ADAM 28	ADAM 7 - epididymis as well as colon; ADAM 28 - variety of tissues including epididymis, lung, lymph node and thymus.
BNP	Heart
C3	Liver
CNP-BPP	Brain
CRISP	Myriad of exocrine tissues including salivary.
Crotasin	Expressed in high levels in the pancreas, and lower but still significant levels expressed in the heart, liver, brain, and kidneys.
E/M/N Cystatin	Restricted to the stratum granulosum of normal skin, the stratum granulosum/spinosum of psoriatic skin, the secretory coils of exocrine sweat glands with low expression levels also found in the nasal cavity.
Endothelin-3	Endothelium
Factor V	Liver
Factor X	Liver
Kallikrein (glandular/tissue)	Variety of exocrine tissues including pancreas as well as the salivary glands.
Kunitz	Wide variety of tissues, including brain, conceptus membrane, lung, ovary, placenta, and uterus.
L-amino oxidase	Variety of exocrine and immune tissues.
Lectin	Myriad
LYNX/SLUR	LYNX - large projection neurons in the hippocampus, cortex and cerebellum; SLUR - granulocytes, expressed in the skin.
β Nerve growth factor	Wide variety of tissues including the brain, eye, prostate and salivary glands.
PLA2 (type IB)	Pancreas.
PLA2 (type IIA)	Synovial fluid and elsewhere.
Prokineticin 2	Expressed at high levels in testis and at lower levels in brain, lung, ovary, spleen, thymus, and uterus.
SPRY	Hemopoietic lineages.
VEGF	Various tissues ranging from the brain to the heart.
Whey acidic peptide	Variety of tissues including lactating mammary gland, lung, ovary, and testis.