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. 2017 Feb 10;127(8):1808–1815. doi: 10.1002/lary.26489

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© 2017 The Authors. The Laryngoscope published by Wiley Periodicals, Inc. on behalf of The American Laryngological, Rhinological and Otological Society, Inc.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Effect of metformin on TUNEL staining in HNSCC. TUNEL was performed on paired premetformin and postmetformin HNSCC samples, and a representative example is shown. Note that there is a postmetformin increase in TUNEL staining in carcinoma cells. Original magnification: 40×. Waterfall plot of the change in GALB intensity between pre‐ and postmetformin samples also is shown. HNSCC = head and neck squamous cell carcinoma; TUNEL = terminal deoxynucleotidyl transferase dUTP nick end labeling.