Table 2.
Prevalence of Warfarin Prescription, Stratified by Severity of Kidney Disease
| eGFR Group | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| ≥120 (N=278) |
105–119 (N=2018) |
90–104 (N=13257) |
60–89 (N=62174) |
45–59 (N=26939) |
30–44 (N=13411) |
15–29 (N=3787) |
<15 (N=679) |
Dialysis (N=645) |
Total (N=123188) |
|
| Warfarin receipt at 90 days | 57.2% | 60.4% | 61.6% | 56.7% | 55.0% | 52.5% | 52.1% | 46.4% | 62.3% | 56.3% |
|
| ||||||||||
| Any warfarin during follow-up | 61.5% | 68.4% | 70.2% | 64.6% | 62.6% | 59.7% | 58.4% | 52.9% | 69.9% | 64.0% |
|
| ||||||||||
| Unadjusted OR of warfarin receipt at 90 days | 0.83 (0.65–1.06) | 0.95 (0.86–1.04) | (reference group) | 0.82 (0.79–0.85) | 0.76 (0.73–0.80) | 0.69 (0.66–0.72) | 0.68 (.63–0.73) | 0.54 (0.46–0.63) | 1.03 (0.88–1.21) | – |
|
| ||||||||||
| Adjusted OR of warfarin receipt at 90 days | ||||||||||
| Full Cohort | 0.53(0.40–0.71) | 0.80 (0.71–0.90) | (reference group) | 1.11 (1.06–1.16) | 1.15 (1.09–1.21) | 1.06 (1.00–1.12) | 1.14 (1.04–1.25) | 0.78 (0.66–0.93) | 1.08 (0.90–1.29) | – |
| CHADS2 ≥ 1 | 0.58(0.41–0.83) | 0.85 (0.73–0.98) | (reference group) | 1.11 (1.05–1.17) | 1.15 (1.09–1.23) | 1.07 (1.00–1.12) | 1.14 (1.03–1.25) | 0.79 (0.66–0.95) | 1.04 (0.87–1.25) | – |
| CHADS2 = 0 | 0.49(0.30–0.80) | 0.77 (0.63–0.94) | (reference group) | 1.08 (0.995–1.18) | 1.07 (0.96–1.21) | 0.94 (0.78–1.13) | 1.09 (0.77–1.56) | 0.58 (0.32–1.06) | 1.69 (0.49–5.78) | – |
| Age ≥ 75 | – | 0.76 (0.41–1.39) | (reference group) | 1.07 (0.94–1.23) | 1.07 (0.94–1.23) | 0.98 (0.86–1.12) | 1.12 (0.95–1.31) | 0.82 (0.63–1.06) | 1.28 (0.92–1.77) | – |
| Age < 75 | 0.66(0.50–0.88) | 0.91 (0.81–1.02) | (reference group) | 1.01 (0.96–1.06) | 1.02 (0.96–1.08) | 0.95 (0.87–1.04) | 1.02 (0.88–1.19) | 0.70 (0.55–0.90) | 0.96 (0.77–1.20) | – |
| Heart Failure | 0.97(0.43–2.19) | 0.83 (0.59–1.15) | (reference group) | 1.14 (0.995–1.31) | 1.16 (1.01–1.34) | 1.11 (0.96–1.29) | 1.24 (1.02–1.51) | 0.79 (0.57–1.10) | 1.03 (0.77–1.38) | – |
| No Heart Failure | 0.48(0.35–0.66) | 0.80 (0.71–0.91) | (reference group) | 1.10 (1.05–1.16) | 1.14 (1.08–1.21) | 1.05 (0.99–1.12) | 1.13 (1.02–1.26) | 0.79 (0.65–0.97) | 1.15 (0.91–1.45) | – |
OR = odds ratio