Table 2.
Genes regulated by the depletion of Hsp70
| Fold change | GenBanka | Gene nameb |
|---|---|---|
| 3.5 | NM_138720 | H2B histone family, member B |
| −27.6 | BC014652 | Hypothetical protein BC002942 |
| −25.9 | NM_003186 | Transgelin |
| −10.0 | Z54367 | Homo sapiens gene for plectin |
| −7.3 | NM_005345 | Heat shock 70 kDa protein 1A |
| −6.6 | NM_054013 | Mannosyl-acetylglucosaminyltransferase |
| −6.0 | NM_005009 | Nonmetastatic cells 4 |
| −5.1 | AC004528 | Homo sapiens chr. 19, cosmid R32184 |
| −4.6 | NM_005451 | Enigma (LIM domain protein) |
| −4.5 | NM_014876 | KIAA0063 gene product |
| −4.2 | NM_005983 | S-phase kinase-associated protein 2 (p45) |
a
GenBank accession number.
b
Genes listed include those differentially regulated 48 h after the transfection of HeLa cells with A1 siRNA as compared to cells transfected with a mismatch siRNA. The cutoff limit in the Affymetrix GeneChip array analysis was set to three-fold for induced genes (+) and four-fold for repressed (−) genes.