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. 2017 Jul 19;8:817. doi: 10.3389/fimmu.2017.00817

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Copyright © 2017 van der Heiden, Boots, Bonacic Marinovic, de Rond, van Maurik, Tcherniaeva, Berbers and Buisman.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MenCWY serum bactericidal antibody responses in participants with and without pre-vaccination rSBA titers. MenC (A), MenW (B), and MenY (C) specific rSBA responses at the different time points for pre-vaccination seronegative (−, red) and seropositive (+, blue) participants. The geometric mean titers are indicated. The seronegative and seropositive participants were compared at the different time points using the Mann–Whitney U test *p < 0.05, ***p < 0.001, and ****p < 0.0001. Reverse cumulative distribution graphs at day 28 and 1 year post-vaccination for MenC (D), MenW (E), and MenY (F) separated for the pre-vaccination seronegative (red) and seropositive (blue) participants.