Table 1.
MenCWY and tetanus toxoid (TT)-specific IgG responses.
| MenC (μg/ml) | MenW (μg/ml) | MenY (μg/ml) | TT (IU/ml) | |
|---|---|---|---|---|
| Pre-GMC [95% CI] | 0.09 [0.06–0.11] | 0.06 [0.04–0.07] | 0.05 [0.04–0.06] | 0.76 [0.63–0.91] |
| Day 7 GMC [95% CI] | 0.67 [0.52–0.86] | 0.13 [0.09–0.16] | 0.11 [0.08–0.14] | 6.81 [5.84–7.94] |
| Ratio day 7/pre [95% CI] | 7.3 [5.9–9.0] | 2.1 [1.7–2.4]****,a | 2.1 [1.8–2.5]****,a | 8.6 [7.4–10.6] |
| Number of fold change > 4 (%) | 120 (58.8%) | 41 (20.1%)****,a | 46 (22.5%)****,a | 146 (71.6%) |
| Day 28 GMC [95% CI] | 13.03 [10.39–16.35] | 2.43 [1.78–3.33] | 3.49 [2.59–4.71] | 13.89 [11.71–16.48] |
| Ratio day 28/pre [95% CI] | 141 [107.5–185.1] | 41.6 [31.4–55.1]****,a/*,b | 67.9 [52.2–88.2]**,a | 18.5 [15.5–22.1] |
| 1 year GMC [95% CI] | 2.60 [2.06–3.28] | 1.99 [1.59–2.51] | 1.89 [1.48–2.41] | 3.51 [3.03–4.07] |
| Ratio day 28/1 year [95% CI] | 5.0 [4.4–5.6] | 1.3 [1.1–1.5]****,a | 1.8 [1.6–2.2]****,a | 3.9 [3.5–4.3] |
The MenC, MenW, and MenY polysaccharide and TT-specific geometric mean concentrations (GMCs [95% CI], in microgram per milliliter) at the different time points pre- and post-vaccination. Moreover, ratios between day 7/pre, day 28/pre, day 28/1 year, and the number of persons with an IgG fold change above four at day 7 are indicated for the different groups.
*p < 0.05, **p < 0.01, ****p < 0.0001.
aCompared to MenC.
bCompared to MenY.
The MenC, MenW, and MenY-specific ratios at day 7, 28, and 1 year were compared with the Mann–Whitney U test after correction for multiple testing. Moreover, the numbers of persons with a fold change >4 at day 7 were compared with the Chi-square test.