Table 4.

MenCWY-specific IgG subclass responses.

Timepoint	Measurement	MenC (μg/ml)	MenW (μg/ml)	MenY (μg/ml)
28 days	IgG1 [95% CI]	3.1 [2.53–3.85]	0.4 [0.30–0.52]	2.3 [1.80–2.83]
	IgG2 [95% CI]	5.1 [3.84–6.67]***,a	0.7 [0.49–1.03]***,a	1.4 [0.97–1.92]**,a
	IgG1/IgG2 ratio [95% CI]	0.6 [0.48–0.81]	0.6 [0.40–0.76]	1.6 [1.19–2.21]
1 year	IgG1 [95% CI]	1.0 [0.82–1.16]	0.6 [0.40–0.76]	1.6 [1.30–1.98]
	IgG2 [95% CI]	1.2 [0.85–1.47]	0.8 [0.63–1.11]**,b	0.8 [0.62–1.13]***,b
	IgG1/IgG2 ratio [95% CI]	0.8 [0.65–1.10]	0.7 [0.50–0.87]	1.9 [1.41–2.51]

Geometric mean concentrations [95% CI] are indicated. Meningococcal group-specific IgG1 and IgG2 responses at the different time points were compared with the Mann–Whitney U test.

**p < 0.01, ***p < 0.001.

^aIgG2 vs IgG1 at day 28.

^bIgG2 vs IgG1 at 1 year.