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. 2004 Jul 29;2004(3):137–142. doi: 10.1155/S1110724304308028

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(a) Uptake of colchicine in KB3-1 expressing with wild-type human P-glycoprotein (KB3-His⁶¹, filled circles), mutant P-glycoprotein in which His⁶¹ was replaced with phenylalanine (KB3-Phe⁶¹, open squares) and serine (KB3-Ser⁶¹, filled squares), and transfected with transfection vector (KB3-Vec, open circles). (b) The ratios between the accumulations of colchicine with and without cyclosporine A (CYA) and (c) PCB-126 (with/without CYA or PCB-126) in KB3-Vec (open columns), KB3-His⁶¹ (cross-hatched columns), KB3-Phe⁶¹ (hatched columns), and KB3-Ser⁶¹ (filled columns). $*$ , $P < .05$ compared to KB3-Vec. Means and SD of 4 experiments.

(a) Uptake of colchicine in KB3-1 expressing with wild-type human P-glycoprotein (KB3-His⁶¹, filled circles), mutant P-glycoprotein in which His⁶¹ was replaced with phenylalanine (KB3-Phe⁶¹, open squares) and serine (KB3-Ser⁶¹, filled squares), and transfected with transfection vector (KB3-Vec, open circles). (b) The ratios between the accumulations of colchicine with and without cyclosporine A (CYA) and (c) PCB-126 (with/without CYA or PCB-126) in KB3-Vec (open columns), KB3-His⁶¹ (cross-hatched columns), KB3-Phe⁶¹ (hatched columns), and KB3-Ser⁶¹ (filled columns). $*$ , $P < .05$ compared to KB3-Vec. Means and SD of 4 experiments.