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Drug tolerance for vinblastine and colchicine in KB3-Vec and KB3-MDR1s, and the ratios for the tolerance of KB3-Vec to KB3-MDR1s (KB3-MDR1s/KB3-Vec).
| KB3-MDR1s | ||||
|---|---|---|---|---|
| KB3-Vec | KB3-His61 | KB3-Phe61 | KB3-Ser61 | |
| Vinblastine (ID50, nM) | 3.4 | 26 | 30 | 40 |
| (KB3-MDR1s/KB3-Vec) | (1) | (7.6) | (8.8) | (11.8) |
| Colchicine (ID50, nM) | 8.8 | 46 | 859 | 43 |
| (KB3-MDR1s/KB3-Vec) | (1) | (5.2) | (97.6) | (4.9) |
Note. Inhibition dose for 50% cell growth (ID50) by adding chemicals was expressed as the index of drug tolerance.
