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. 2017 Jul 18;7:5744. doi: 10.1038/s41598-017-06057-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Brain regions showing significant correlations between gray matter volume and clinical characteristics or cognitive function. (a) The brain region showed positive correlations with scores of Young’s Internet addiction test in Internet gaming disorder group (IGD). The scatter plot at right depicts the relation between mean gray matter volume from the significant cluster and IAT scores in IGD. (b) The brain regions showed negative correlation with addiction duration of alcohol use disorder (AUD). The scatter plot at right depicts the relation between mean gray matter volume from the significant cluster and addiction duration of AUD. (c) The brain regions showed negative correlation with total errors of spatial span in AUD group. The scatter plot at right depicts the relation. These correlations were not significant after correctios for multiple comparisons. between mean gray matter volume from the significant cluster and total errors of spatial span in AUD group. AUD, alcohol use disorder; IGD, Internet gaming disorder; IAT, Young’s Internet addiction test; SSP, spatial span.