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. 2017 Jul 18;7:5685. doi: 10.1038/s41598-017-05864-2

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Differential C9orf72 promoter activity in cortical and spinal cord astrocytes. (a) Representative images of layer 5 (L5) in primary motor cortex (M1, top) and the ventral horn of the spinal cord (SC, bottom) of C9orf72 ^LacZ/+ mice immunostained for S100β-positive astrocytes (green), Olig2-positive oligodendrocyte lineage cells (cyan), and β-gal (red). Asterisks indicate S100β-positive Olig2-positive oligodendrocyte lineage cells and S100β-positive motor neurons which were excluded from the analysis. High magnification images show an astrocyte in motor cortex which lacks β-gal puncta (top right) and astrocytes in the spinal cord which contain β-gal puncta (bottom right). Scale bars: 50 μm and 10 μm. Percentage of astrocytes containing β-gal puncta in L5 of primary motor and primary somatosensory cortex (b) L5 motor cortex: 1 of 92 cells, 1.1%, L5 somatosensory cortex, 1 of 98 cells, 1.0%, n = 3 mice for each group, p = 0.9641, Chi-Square test) and spinal cord (c) dorsal spinal cord: 15 of 84 cells, 17.9%, ventral spinal cord: 16 of 78 cells, 20.5%, n = 3 mice for each group, p = 0.6676, Chi-Square test).