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. 2017 Jul 18;7:5718. doi: 10.1038/s41598-017-06408-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Analysis of behavioral parameters. The list of the choice-related behavioral parameters is as follows: reward latency (R.L), premature response (Pre), omission (Om), perseverative response (Per), correct response latency (C.L), and feed-tray entry (F.E). Each parameter’s units of measurement are as follows: R.L. (sec), Pre (%), Om (%), Per (actual number of touch), C.L. (sec), F.E (the number of feed-tray entries during ITI divided by total number of trials initiated). Data for these parameters obtained on the challenge day were analyzed using the independent sample t-test and compared between the saline and cocaine pre-exposed rats. In the averse-paired and seeking-paired groups, only differences for reward latency were significant between the saline and cocaine pre-exposed sub-groups. In the seeking-isolated group, differences in the premature and perseverative responses were significant between the saline and cocaine pre-exposed sub-groups. Interestingly, in the averse-isolated group, which did not show any change in choice preference upon the cocaine challenge, differences for the parameters such as omission, correct response latency, and feed-tray entries were significant between the saline and cocaine pre-exposed sub-groups.