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. 2017 Jul 18;7:5718. doi: 10.1038/s41598-017-06408-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Locomotor activity. (a) During the cocaine challenge, locomotor activity (combined score of the horizontal locomotion and rearing) was significantly higher (i.e., locomotor sensitization) in cocaine compared to the saline pre-exposed sub-groups, but only in the averse-isolated group. (b) When the groups were combined and compared according to the housing environment (i.e., paired vs. isolated), locomotor sensitization only occurred in the isolated groups. (c) There was no significant difference between the averse and seeking groups when combined.