Table 1.
Transcription factor regulation enrichment for genes included in the genome-wide transcripcional response to caspofungin.
| Transcription Factor | % DRA | p-value | % TF-binding sites | Description |
|---|---|---|---|---|
| Slt2-dependent genes | ||||
| Rlm1 | 81.94 | 0.00E+00 | 66.67 | CWI MAPK pathway |
| Gcn4 | 75.00 | 3.12E-09 | 68.05 | Amino acid biosynthesis |
| Ste12 | 80.56 | 6.95E-07 | 25.00 | Mating MAPK pathway |
| Tec1 | 79.17 | 1.76E-06 | 80.55 | Filamentous growth |
| Ace2 | 87.50 | 1.82E-05 | 22.22 | Cell separation (M/G1 transition) |
| Slt2-independent genes | ||||
| Msn2 | 94.24 | 0.00E+00 | 80.57 | Response to stress |
| Msn4 | 86.33 | 0.00E+00 | 80.57 | Response to stress |
| Gcn4 | 86.61 | 0.00E+00 | 61.15 | Amino acid biosynthesis |
| Bas1 | 92.09 | 0.00E+00 | 30.21 | Purine and histidine biosynthesis |
| Swi5 | 75.54 | 0.00E+00 | 25.17 | M/G1 phase gene expression |
| Tec1 | 79.86 | 2.47E-11 | 79.86 | Filamentous growth |
| Ace2 | 89.21 | 2.59E-10 | 25.17 | Cell separation (M/G1 transition) |
| Ste12 | 75.54 | 5.02E-08 | 17.26 | Mating MAPK pathway |
DRA, percentage of genes showing documented regulatory associations with transcription factors (p-value < 0.001) as deduced from analysis with YEASTRACT. Those transcription factors with DRA percentages higher than 75%, ordered by p-value, are shown. Percentage of genes showing in their promoters at least one DNA-binding domain for each indicated transcription factor is also included.