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. 2017 Jul 19;9:229. doi: 10.3389/fnagi.2017.00229

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Copyright © 2017 Porrini, Mota, Parrella, Bellucci, Benarese, Faggi, Tonin, Spano and Pizzi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GFAP immunoreactivity in c-rel^−/− and wt mice. Pictures of SN sections from 4- (A,B), 13- (C,D) and 18-month-old (E,F) animals illustrating GFAP astroglial immunostaining. No evident changes in astroglial activation were found in c-rel^−/− mice (B,D,F) compared to age-matched wt (A,C,E). Immunofluorescence images are representative of five sections from each animal (n = 3 animals per group). Abbreviations: GFAP, glial fibrillary acidic protein; SN, substantia nigra. Scale bar: in (A) = 100 μm for (A–F).