Table 2.
Property | P21 +/+ | P21 −/− | Adult +/+ | Adult−/− |
---|---|---|---|---|
Resting membrane potential | ⇔ | ⇔ | ⇓ | ⇑ |
Membrane resistance | ⇓ | ⇑ | ⇓ | ⇑ |
Membrane time constant (tau) | ⇓ | ⇑ | ⇓ | ⇑ |
Firing rate | ⇓ | ⇑ | ⇓ | ⇑ |
G-protein signaling | ⇑ | ⇓ | n/a | n/a |
Action potential threshold | ⇑ | ⇓ | ⇑ | ⇓ |
Afterhyperpolarization amplitude | ⇓ | ⇑ | ⇓ | ⇑ |
+/+ is wildtype and −/− is Pet-1−/−. Arrows indicate changes in properties and are relative to the alternate genotype at the same age. Left-right arrows indicate no difference. G-protein signaling was only assayed at postnatal day 21 (P21).