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. 2017 Jul 18;7:5738. doi: 10.1038/s41598-017-05936-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Impact of chrysin and its derivatives on platelet activation in platelet-rich plasma. Human platelet-rich plasma was treated with vehicle control [0.1% (v/v) DMSO] or a range of concentrations of chrysin (A,B), thio-chrysin (C,D), Ru-chrysin (E,F) and Ru-thio-chrysin (G,H) for 5 minutes prior to the addition of 0.5 μg/mL CRP-XL in an optical aggregometer. The platelet aggregation was monitored for 5 minutes. The traces shown are representative of three separate experiments. The maximum aggregation obtained with vehicle control at 5 minutes was taken as 100% to calculate the level of aggregation for chrysin and its derivatives-treated samples. Cumulative data represent mean ± S.D. (n = 3). *Indicates significance with respect to controls and ^#indicates significance with respect to the respective chrysin concentrations, p values shown (**^,## p < 0.01 and ***^,### p < 0.001) are as calculated by one-way ANOVA using Graphpad Prism.