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. 2017 Jul 19;11:201. doi: 10.3389/fncel.2017.00201

Figure 2.

Figure 2

Photothrombosis induced focal ischemic injury to the sensorimotor cortex persists in IRF2BP2KO mice at 4 days. (A) Cresyl violet staining reveals lesion area where neurons are lost and devoid of stain. Representative brain sections from IRF2BP2KO (KO) and littermate control mice (WT) 4 days after photothrombosis-induced stroke injury. (B) High power magnification showing the clear demarcation of the ischemic core (IC). Left scale bar, 200 μm; right scale bar, 100 μm. (C) Immunofluorescence labeling of Iba+ microglia recruited to the IC and activation of astrocytes revealed by glial fibrillary acidic protein (GFAP). Neurons (NeuN+) are absent in the IC. Scale bar, 200 μm. The corresponding region of the contralateral (non-ischemic) side, with few Iba1+ microglia, is shown for comparison. (D) Lesion regression is delayed in KO mice. N = 10–15 mice/group. *p < 0.05.