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. 2017 Jul 18;7:5768. doi: 10.1038/s41598-017-06406-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The p38 MAPK signaling pathway is involved in the increased expression of HO-1 induced by 5-ALA. (A) The ARE reporter assay. (B–E) qRT-PCR analysis of the effects of 5-ALA on the mRNA expression level of HO-1 (B), NQO1 (C), GCLM (D), and GCLC (E). (F,G) Western blot analysis showing the effect of the p38 MAPK inhibitor SB203580 (SB) on 5-ALA-induced expression of HO-1. Each value represents the mean ± SEM of three determinations, based on the untreated culture (control). The significance of any difference was determined using ANOVA, followed by the Bonferroni/Dunn post-hoc test (*p < 0.05 versus control; ^† p < 0.05, ^†† p < 0.01 versus treatment with 0.5 mM Pi).

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