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. 2017 Jul 18;7:5781. doi: 10.1038/s41598-017-06173-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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GSK-3β deletion in DG induces an anti-anxiety behavior. (a) The representative route recorded in open field test. (b–d) GSK-3β deletion reduced the percentage time spent in corner without changing the time spent in the center and the total distance moved in the open field test.(Vector, n = 10; Cre, n = 8, unpaired t test) (e) The representative route in the elevated maze test. (f–h) GSK-3β deletion increased the percentage of open arm entries, the percentage distance and total time spent in the open arm(Vector, n = 10; Cre, n = 8, unpaired t test). Data were presented as mean ± s.e.m. *P < 0.05, **P < 0.01 versus Vector; the absence of asterix indicates that the difference is not significant.