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. 2017 Jul 18;7:5691. doi: 10.1038/s41598-017-05932-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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TRAIL induces a pro-inflammatory expression profile in human preadipocytes and adipocytes. SGBS preadipocytes and adipocytes on day 14 of adipogenic differentiation were treated with TRAIL (+)(30 ng/ml) or vehicle (−) as indicated. After 12 hours, RNA was harvested and subjected to mRNA array analysis (GeneChip Human Gene 1.0 ST Array; Affymetrix). Heatmaps display the TRAIL-regulated inflammatory genes in preadipocytes (A) and adipocytes (B). An evidence-based STRING 10 analysis was performed to visualize the network of TRAIL-regulated genes in preadipocytes and in adipocytes (C).