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. 2016 Dec 28;91(8):2921–2938. doi: 10.1007/s00204-016-1918-1

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — KI effects on mitochondrial oxygen consumption. Rat liver mitochondria were incubated with KIs at 100-fold Cmax or the maximal testable concentrations as indicated. The KIs in the X-axis were listed according to their approval date. The six KIs with a black box warning for hepatotoxicity were highlighted in a red box. The Y-axis represents the fold changes of oxygen consumption after KI treatment as compared to DMSO-treated samples. a, b Represent the oxygen consumption rate measured using glutamate/malate and succinate, respectively. Data are means and standard derivations from three separate experiments. *p < 0.05 as compared to DMSO-treated samples (color figure online)