. 2016 Dec 28;91(8):2921–2938. doi: 10.1007/s00204-016-1918-1

Table 5.

Prediction of KI hepatotoxicity by using mitotoxicity at different concentrations

Fold of Cmax	Test system	Mitotoxicity	DILI+	DILI−	PPV	NPV	Sensitivity	Specificity
100	Intact-mito (excluded 3 drugs)	+	10	5	67%	31%	53%	44%
	Intact-mito (excluded 3 drugs)	−	9	4	67%	31%	53%	44%
	Intact and Sub-mito (excluded 1 drug)	+	13	5	72%	33%	62%	44%
	Intact and Sub-mito (excluded 1 drug)	−	8	4	72%	33%	62%	44%
1	Intact-mito	+	3	0	100%	32%	14%	100%
	Intact-mito	−	19	9	100%	32%	14%	100%
	Intact and Sub-mito	+	3	0	100%	32%	14%	100%
	Intact and Sub-mito	−	19	9	100%	32%	14%	100%

PPV positive predictive value, NPV negative predictive value, DILI drug-induced liver injury. A drug is considered as mitotoxicity positive (+) if it causes at least one type of mitochondrial injury. Intact-mito: data from whole mitochondria; Sub-mito: data from submitochondrial particles